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KMID : 0370019980120000067
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Chung-Ang Journal of Pharmacal Sciences
1998 Volume.12 No. 0 p.67 ~ p.72
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Effects of Oregonin, diarylheptanoid derivative from plant on antitumor
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Abstract
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Oregonin, a diarylheptanoid derivative from Alrus hirsuta Turcz, Betulaceae was evaluated on the antitumor activity. Oregonin, a diarylheptarioid zyloside is a novel immunomodulator augmenting macrophage and natural killer cell activity related anti-tumor functions. To investigate cytotoxicity of oregonin on tumor cells, the effect of the substance on three cell lines(P815, Yac-1, B16-F10) was examined. The result was somewhat different between suspension and adhesion cells. The growth-rate of suspension cells(P815, Yac-1) was not cut down significantly, but in contrast, the inhibitory activity on adhesion cell(B16-F10) was effective. Its ED50 is 20.09㎍/㎖(4.19×10^-5mol/l)
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